Comparison of the effects of bleomycin and ionizing radiation in two sublines of murine lymphoma L5178Y
نویسندگان
چکیده
Bleomycin (BLM) is an anticancer antibiotic isolated from the supernatant of Streptomyces verticillus culture [21]. The cytotoxic activity of BLM depends on generation of singleand double-strand breaks in DNA (for review, see [16]). Indispensable for this BLM activity is the presence of metal ions, specifically Fe2+. Fe2+ BLM complexed with O2 or Fe 3+ BLM complexed with H2O2 leads to formation of an active BLM molecule, HOO–• Fe3+ • BLM.
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